Abstract

Research Article

Severe brimonidine eye drop intoxication in a neonate as an accidental oral ingestion

Musa Silahli*

Published: 04 January, 2022 | Volume 5 - Issue 1 | Pages: 001-003

Brimonidine tartrate eye drops are a topical agent used to treat glaucoma in children over 2 years of age and adults. It is banned for children younger than 2 years of age because post-marketing studies have shown serious side effects. Colic is common in infants, which worries parents. And parents often use herbal and chemical medicines to solve this problem. We present a 12-day-old newborn with brimonidine eye drop intoxication, in which the drug was mistakenly administered orally to treat the colic problem.

Read Full Article HTML DOI: 10.29328/journal.japch.1001044 Cite this Article Read Full Article PDF

References

  1. Levy Y, Zadok D. Systemic side effects of ophthalmic drops. Clin Pediatr (Phila). 2004; 43: 99-101. PubMed: https://pubmed.ncbi.nlm.nih.gov/14968900/
  2. Gray C. Systemic toxicity with topical ophthalmic medications in children. Paediatr Perinat Drug Ther. 2006; 7: 23-29.
  3. Alphagan P. Irvine, CA: Allergan Incorporated; 2007
  4. Kiryazov K, Stefova M, Iotova V. Can ophthalmic drops cause central nervous system depression and cardiogenic shock in infants? Pediatr Emerg Care. 2013; 29: 1207-1209. PubMed: https://pubmed.ncbi.nlm.nih.gov/24196091/
  5. Al-Shahwan S, Al-Torbak AA, Turkmani S, et al. Side-Effect profile of Brimonidine Tartrate in Children. 2005; 12: 2143-2148. PubMed: https://pubmed.ncbi.nlm.nih.gov/16225927/
  6. Lai Becker M, Huntington N, Woolf AD. Brimonidine tartrate poisoning in children: frequency, trends, and use of naloxone as an antidote. Pediatrics. 2009; 123: 305-311. PubMed: https://pubmed.ncbi.nlm.nih.gov/19124581/
  7. Bowman RJC, Cope J, Nıschal KK. Ocular and systemic side effects of brimonidine 0.2% eye drops (Alphagan®) in children. Eye. 2004; 18: 24-26. PubMed: https://pubmed.ncbi.nlm.nih.gov/14707960/
  8. Ghaffari Z, Zakariaei Z, Ghazaeian M, Jafari R, Ezoddin N, et al. Adverse effects of brimonidine eye drop in children: A case series. J Clin Pharm Ther. 2021; 46: 1469-1472. PubMed: https://pubmed.ncbi.nlm.nih.gov/33626597/
  9. Deslandes G, Bouquié R, Boels D, Grégoire M, Grison-Hernando H, et al. Accidental poisoning with brimonidine eye drops in a 9-day-old infant. Toxicologie Analytique et Clinique. 2015; 27: 14-17.

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Similar Articles

Recently Viewed

  • Biologic therapy in severe asthma: An update
    Maha A Al Ammari* Maha A Al Ammari*. Biologic therapy in severe asthma: An update. Arch Asthma Allergy Immunol. 2019: doi: 10.29328/journal.aaai.1001016; 3: 003-009
  • Sanitary update on wheat in Argentina
    Enrique Javier Alberione* Enrique Javier Alberione*. Sanitary update on wheat in Argentina. J Plant Sci Phytopathol. 2022: doi: ; 6: 087-090
  • Physical activity can change the physiological and psychological circumstances during COVID-19 pandemic: A narrative review
    Khashayar Maroufi* Khashayar Maroufi*. Physical activity can change the physiological and psychological circumstances during COVID-19 pandemic: A narrative review. J Sports Med Ther. 2021: doi: 10.29328/journal.jsmt.1001051; 6: 001-007
  • An unusual presentation of atrioventricular nodal reentrant tachycardia
    Florina-Adriana Ghitun, Stefan Ailoaei, Dan Ursu, Raluca Chistol, Grigore Tinica, Mihaela Grecu, Mihaela Grecu*, Florina-Adriana Ghitun, Stefan Ailoaei, Dan Ursu, Raluca Chistol, Grigore Tinica and Cristian Statescu Florina-Adriana Ghitun,Stefan Ailoaei,Dan Ursu,Raluca Chistol,Grigore Tinica,Cristian Statescu,Mihaela Grecu,Mihaela Grecu*,Florina-Adriana Ghitun,Stefan Ailoaei,Dan Ursu,Raluca Chistol,Grigore Tinica,Cristian Statescu. An unusual presentation of atrioventricular nodal reentrant tachycardia. J Cardiol Cardiovasc Med. 2021: doi: 10.29328/journal.jccm.1001110; 6: 014-018
  • pVAD-assisted left main DK-Crush Bifurcation PCI Post-ViV TAVR
    Anshuman Das*, Maria Isabel Camara Planek, Steve Attanasio, Steve Attanasio*, Maria Isabel Camara Planek and Anshuman Das Anshuman Das*,Maria Isabel Camara Planek,Steve Attanasio,Steve Attanasio*,Maria Isabel Camara Planek,Anshuman Das. pVAD-assisted left main DK-Crush Bifurcation PCI Post-ViV TAVR. J Cardiol Cardiovasc Med. 2021: doi: 10.29328/journal.jccm.1001114; 6: 029-032

Read More

Most Viewed

Read More