Abstract

Case Report

Celiac disease presenting as transient intussusception in two 3-year-olds

Gergely Tóth*

Published: 21 June, 2023 | Volume 6 - Issue 1 | Pages: 031-032

Although intussusception occurs in children and adults with celiac disease, it is a relatively uncommon symptom. Even more rare is the occurrence of intussusception as the presenting symptom of the disease. In the two cases we report here, transient intussusception, occurring at three years of age, was the first and only physical sign of celiac disease, and lead to a timely diagnosis by immunoserology and histology, followed by implementation of a gluten-free diet before sequelae such as significant anemia or Failure to Thrive (FTT) developed. In both cases, neither immunoserological nor physical signs of disease were present at the follow-up examination after 6 months on a gluten-free diet. In addition, genetic screening of the patients’ families revealed HLA-DQ2 positivity in two cases, leading to the additional diagnosis of celiac disease in the pregnant mother of one of the patients.

Read Full Article HTML DOI: 10.29328/journal.japch.1001057 Cite this Article Read Full Article PDF

References

  1. Goyal P, Nohria S, Singh Grewal C, Sehgal R, Goyal O. Celiac disease and intussusception - a rare but important association. Acta Gastroenterol Belg. 2022 Jan-Mar;85(1):111-112. doi: 10.51821/85.1.7959. PMID: 35305004.
  2. Brown NK, Guandalini S, Semrad C, Kupfer SS. A Clinician's Guide to Celiac Disease HLA Genetics. Am J Gastroenterol. 2019 Oct;114(10):1587-1592. doi: 10.14309/ajg.0000000000000310. PMID: 31274511.
  3. Borkar VV, Poddar U, Thakral A, Agarwal J, Srivastava A, Yachha SK, Kumar S. Intussusception in celiac disease: Is it a common feature in children? J Gastroenterol Hepatol. 2018 Feb;33(2):380-384. doi: 10.1111/jgh.13865. PMID: 28688105.

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