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Submitted: August 18, 2025 | Approved: August 30, 2025 | Published: September 01, 2025
How to cite this article: Ghosh S. Necrotizing Fasciitis in Neonates Case Series. J Adv Pediatr Child Health. 2025; 8(2): 015-017. Available from:
https://dx.doi.org/10.29328/journal.japch.1001073
DOI: 10.29328/journal.japch.1001073
Copyright License: © 2025 Ghosh S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Neonate; Necrotising fasciitis; Sepsis
Invasive Magnusiomyces Capitatus Infection in a Patient Followed for Acute Myeloblastic Leukemia: A Case Report
Saugat Ghosh*
Tripura Medical College and Dr. BRAM Teaching Hospital, India
*Address for Correspondence: Saugat Ghosh, Tripura Medical College and Dr. BRAM Teaching Hospital, India, Email: [email protected]
Introduction: Necrotizing Fasciitis (NF) is a rapidly progressing and life-threatening soft tissue infection, exceedingly rare but often fatal in neonates. This case series highlights the rarity, fulminant nature, and poor prognosis of neonatal NF by presenting four cases.
Case presentation: Four neonates, aged 12-16 days, presented with rapidly spreading, tender, erythematous, and indurated skin lesions on their backs, initially resembling burns. Systemic symptoms like fever, lethargy, and poor feeding were common. Despite empirical antibiotics, the lesions progressed to necrosis, often with bullae formation. Microbiological cultures revealed polymicrobial growth in three cases (E. coli, Pseudomonas sp., Klebsiella, and MRSA) and monomicrobial growth of MRSA in one case, frequently exhibiting antibiotic resistance. Surgical debridement was performed in three cases. Despite aggressive management, two neonates succumbed to sepsis and multi-organ dysfunction. The other two neonates recovered after prolonged antibiotic therapy and wound care.
Discussion: These cases underscore the diagnostic challenges and rapid progression of NF in neonates. The consistent presentation after 10 days of birth, rapid lesion spread mimicking burns, and predilection for the back were notable features. Polymicrobial infection was frequent. Early recognition, aggressive broad-spectrum antibiotics, and timely surgical debridement are crucial for improving the poor prognosis associated with this condition.
Necrotizing Fasciitis (NF) is a life-threatening soft tissue infection that is characterized by rapid and fulminant progression. The incidence of NF in children is around 0.08 per 100,000 population [1]. This case series reports 4 cases of NF due to its rarity, fulminant nature, and poor prognosis.
4 term newborns with uneventful birth and postnatal history were admitted with necrotic skin areas on the back, looking like a burn, which developed aggressively over a period of 1-2 days. They were all delivered at the hospital, and all the babies were on breastfeeding. Along with the local lesion, there were multiple systemic features. Septic parameters were deranged in all. Multiple prolonged antibiotic therapies, surgical debridement, and thrice daily dressing were done in all the cases. The pus culture and blood culture revealed growth of highly pathogenic and resistant organisms. Despite aggressive antibiotic therapy and surgical debridement, 2 babies died, and 2 babies were discharged. The clinical features and management are described as under (Table 1, Figures 1-5).
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Case 1 | Case 2 | Case 3 | Case 4 | |
Age(days) | 12 | 16 | 13 | 18 |
Weight(kg) | 3.34 | 2.6 | 3.46 | 2.8 |
Sex | Girl | Boy | Boy | Female |
Mode of delivery | LSCS* | NVD# | LSCS | LSCS |
Complications during or after delivery | No | No | No | No |
Clinical features | Febrile, lethargic, and not accepting feeds | fever, high-pitched cry, and poor feeding, oliguria | Fever, poor feeding | Fever, poor feeding |
Duration of symptoms | 24 hrs | 48hrs | 1-2 days | 24 hrs |
Skin manifestation | Large area of tender, indurated, brownish-red necrotic area, looking like a burn, with 1 bulla in his back, which rapidly spread over the past 24 hours. | Extensive indurated, erythematous, tender, brownish-red area on the entire back, looking like a burn. There were multiple haemorrhagic bullae, which were oozing blood mixed with serous fluid. | Dirty-looking dark necrotic ulcer in the lumbosacral area measuring approximately 10x10 cm, with surrounding erythema and induration, with oozing of serous fluid | Localised red hard tender area measuring approximately 8x10cm in the lower back |
Other notable features | no | Down's phenotype. Irritable, hypotension, extensive sclerema, thrombocytopenia, Gastrointestinal bleed, haematuria, AKI##, and DIC*** | Differential diagnosis of infected meningomyelocele or burn was made. Ultrasonography of the local site was done, which revealed an intact spinal canal. | Seizure. |
Total Leucocyte Count (cu mm) | 26,500 | 25600 | 24000 | 21000 |
C.Reactive Protein(<5mg/dl) | 85.7 | 35 | 36 | 53 |
Wound culture | E.Coli sensitive to only colistin | MRSA** | Klebsiella and MRSA. Klebsiella was pan-resistant and intermediately sensitive to Amikacin. | Pseudomonas and E. coli, which were sensitive to only cefepime and colistin |
Blood culture | Pseudomonas, carbapenem resistant | sterile | Pseudomonas-carbapenem resistant | Sterile |
Surgical debridement | Yes | Yes | Yes | Yes |
Skin biopsy | Neutrophil infiltrates, fibrosis with unhealthy granulation tissue | Necrotic tissues | Necrotic tissues | Necrotic tissues |
Duration of NICU stay | 21 days | 30 hours | 14 days | 23days |
Outcome | expired | expired | discharged | Discharged |
Abbreviations: LSCS*: Lower Segment Caesarean Section; NVD: -Normal Vaginal Delivery; MRSA**: Methicillin-resistant Staphylococcus aureus; AKI##: Acute Kidney Injury; DIC***: Disseminated Intravascular Coagulation |
Figure 1: Case 1.
Figure 2: Skin biopsy Case 1.
Figure 3: Case 2.
Figure 4: Case 3.
Figure 5: Case 4.